Literature summary extracted from

Mori, Y.; Kono, K.; Matsumoto, Y.; Fujii, H.; Yamane, T.; Mitsumata, M.; Chen, W.T.
The expression of a type II transmembrane serine protease (Seprase) in human gastric carcinoma (2004), Oncology, 67, 411-419.

Application

EC Number	Application	Comment	Organism
3.4.21.B28	medicine	role in the invasive and metastatic progression of gastric carcinoma, tendency towards a worse prognosis in patients whose tumors exhibit high levels of the 170000 Da seprase dimer	Homo sapiens

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
3.4.21.B28	97000	-	Western immunoblotting, monomer	Homo sapiens
3.4.21.B28	170000	-	Western immunoblotting, dimer	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.B28	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.B28	endothelial cell	weakly located in microvessel endothelial cells	Homo sapiens	-
3.4.21.B28	fibroblast	-	Homo sapiens	-
3.4.21.B28	gastric cancer cell	mainly located, seprase-expressing carcinoma tissue more often found in the scirrhous type than in other types of gastric carcinoma	Homo sapiens	-
3.4.21.B28	additional information	absent in normal tissue	Homo sapiens	-
3.4.21.B28	stromal cell	weakly located	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.B28	Gelatin + H2O	seprase-dimer	Homo sapiens	?	-	?

Subunits

EC Number	Subunits	Comment	Organism
3.4.21.B28	dimer	Western immunoblotting, 76% expression frequency	Homo sapiens
3.4.21.B28	monomer	Western immunoblotting	Homo sapiens

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.B28	seprase	-	Homo sapiens
3.4.21.B28	type II transmembrane serine protease	-	Homo sapiens

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Release 2023.1 (January 2023)